APEX | The 28 Ingredients Behind APEX
Inside The Bottle

The 28 Ingredients
Behind APEX.

Every milligram printed on the label. Every dose backed by peer-reviewed research. No proprietary blends. No fillers. No fluff.

28
Ingredients
100+
Studies Reviewed
0
Hidden Blends
Black MacaAM350mgBlack Maca · Lepidium meyenii+

A Peruvian root grown 14,000 feet above sea level in the Andes mountains. Black maca is the rarest of the maca varieties — and the one most studied for energy, stamina, and male vitality.

  • Supports daily energy and physical stamina
  • Helps maintain healthy male vitality
  • Used in traditional Peruvian medicine for 2,000+ years
  • Adaptogenic — helps the body respond to stress
14,000 ft
Andes elevation where authentic black maca is grown
2,000+
Years of documented use in Peruvian traditional medicine
Backed By Research
Gonzales et al., 2002 (Andrologia)Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.
Stone et al., 2009 (J Ethnopharmacol)A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen.
L-TyrosineAM340mgL-Tyrosine · Free-form amino acid+

A precursor amino acid used by the body to produce dopamine, norepinephrine, and adrenaline — the neurotransmitters that drive focus, motivation, and mental energy. Studied extensively by the U.S. military for performance under stress.

  • Supports the production of focus-related neurotransmitters
  • Helps maintain mental performance under stress
  • Used in research for cognitive support during sleep deprivation
  • Naturally found in cheese, where it gets its name (Greek: tyros)
3
Key neurotransmitters the body builds from L-tyrosine
1846
Year tyrosine was first isolated from cheese protein
Backed By Research
Jongkees et al., 2015 (J Psychiatr Res)Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands — A review.
Neri et al., 1995 (Aviat Space Environ Med)The effects of tyrosine on cognitive performance during extended wakefulness.
BacopaAM300mgBacopa · Bacopa monnieri+

An aquatic herb known in Ayurveda as "Brahmi" — used for over 3,000 years to support memory and cognitive function. Modern research has focused on its bacosides, the compounds responsible for its nootropic effects.

  • Supports memory formation and recall
  • Helps maintain cognitive performance over time
  • Studied for its effects on attention and learning
  • Traditional adaptogenic herb in Ayurvedic medicine
3,000+
Years of documented use in Ayurvedic tradition
12 weeks
Typical study duration to observe cognitive effects
Backed By Research
Kongkeaw et al., 2014 (J Ethnopharmacol)Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.
Stough et al., 2008 (Phytother Res)Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning.
Tongkat AliAM250mgTongkat Ali · Eurycoma longifolia root extract+

A flowering plant native to Southeast Asia, also known as Malaysian Ginseng. Tongkat Ali has been studied for over 50 years in Malaysia, with multiple peer-reviewed clinical trials examining its effects on stress, hormonal balance, and male vitality in aging men.

  • Supports healthy hormonal balance in aging men
  • Helps maintain natural energy and vitality
  • Studied in randomized placebo-controlled clinical trials
  • Traditional adaptogen in Malaysian and Indonesian medicine
50+
Years of clinical research in Malaysia
700+
Products globally use this ingredient
Backed By Research
Leisegang et al., 2022 (Medicina)Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials.
Leitão et al., 2021 (Maturitas)A 6-month, double-blind, placebo-controlled, randomized trial on Eurycoma longifolia in androgen deficiency of aging males.
RhodiolaAM200mgRhodiola · Rhodiola rosea root+

An arctic flowering plant that grows at high altitudes in Siberia, Scandinavia, and the Rocky Mountains. Used by Vikings to enhance physical strength and by Soviet cosmonauts and Olympic athletes to support performance under stress.

  • Helps the body adapt to physical and mental stress
  • Supports natural energy and stamina
  • Helps maintain mental performance during fatigue
  • Classified as an adaptogen with extensive Russian research
3,500m
Altitude where the most potent rhodiola grows
200+
Soviet research papers published on rhodiola
Backed By Research
Panossian et al., 2010 (Phytomedicine)Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
Olsson et al., 2009 (Planta Med)A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of Rhodiola rosea in stress-related fatigue.
Korean Panax GinsengAM200mgKorean Panax Ginseng · Panax ginseng root+

The most studied form of ginseng in the world. The genus name Panax comes from the Greek word for "all-healing" — coined in 1843 by botanist Carl Anton Meyer for its broad therapeutic reputation in Asian medicine.

  • Supports daily energy and stamina
  • Helps maintain cognitive performance
  • Adaptogenic — supports stress response
  • Traditional staple of Korean and Chinese medicine
2,000+
Years of documented use in Asian medicine
6 years
Time required to mature roots before harvest
Backed By Research
Geng et al., 2010 (Cochrane Database)Ginseng for cognition: A systematic review of randomized controlled trials.
Reay et al., 2010 (J Psychopharmacol)Effects of Panax ginseng on cognitive performance and feelings of fatigue.
Coleus ForskohliiAM150mgColeus Forskohlii · Plectranthus barbatus root+

A member of the mint family found in the subtropical regions of India, Burma, and Thailand. The active compound forskolin was isolated in 1974 and remains one of the most-studied molecules in cellular biology research.

  • Supports healthy metabolic function
  • Helps maintain lean body composition
  • Used in Ayurvedic medicine for centuries
  • Studied for cellular cAMP activation
1974
Year forskolin was first isolated by researchers
10%
Standardized forskolin extract commonly used in research
Backed By Research
Godard et al., 2005 (Obes Res)Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.
Broccoli Seed ExtractAM100mgBroccoli Seed Extract · Brassica oleracea (sulforaphane source)+

The concentrated source of sulforaphane — a compound found to be 10 to 100x more concentrated in broccoli sprouts and seeds than in mature broccoli. Discovered by researchers at Johns Hopkins in 1992.

  • Supports the body's natural detoxification pathways
  • Studied for cellular antioxidant support
  • Helps maintain healthy cellular function
  • Activates the Nrf2 pathway in research models
1992
Year sulforaphane was discovered at Johns Hopkins University
100x
Higher sulforaphane concentration in seeds vs mature broccoli
Backed By Research
Fahey et al., 1997 (PNAS)Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
CordycepsAM30mgCordyceps · Cordyceps sinensis / militaris+

A medicinal mushroom traditionally harvested from the Tibetan plateau at elevations above 11,000 feet. Used by Chinese Olympic athletes in the 1990s — sparking global interest in its potential for endurance and oxygen utilization.

  • Supports natural energy and aerobic capacity
  • Helps maintain healthy oxygen utilization
  • Adaptogenic mushroom used in Tibetan medicine
  • Studied for athletic performance support
11,000 ft
Elevation where wild cordyceps grows in Tibet
1993
Year Chinese athletes broke world records, citing cordyceps
Backed By Research
Hirsch et al., 2017 (J Diet Suppl)Cordyceps militaris improves tolerance to high-intensity exercise after acute and chronic supplementation.
Thiamin (B1)AM10mgThiamin (B1) · Thiamine HCl+

The first B vitamin discovered, isolated in 1926. Essential for converting carbohydrates into energy and for proper nervous system function. The body cannot store thiamin, so daily intake is critical.

  • Essential for energy metabolism from food
  • Supports healthy nervous system function
  • Helps maintain mental focus and alertness
  • Required cofactor for hundreds of metabolic reactions
1926
Year thiamin was first isolated — earned a Nobel Prize
833%
Of the recommended daily value in this dose
Backed By Research
NIH Office of Dietary SupplementsThiamin Fact Sheet for Health Professionals.
BioPerine®AM10mgBioPerine® · Piper nigrum (95% piperine)+

The patented standardized extract of black pepper, containing 95% piperine. Studied for its ability to increase the bioavailability of other nutrients by up to 30% — meaning more of every other ingredient actually reaches your bloodstream.

  • Increases bioavailability of co-administered nutrients
  • Supports the absorption of fat-soluble compounds
  • Patented extract from Sabinsa Corporation
  • Used in 100+ peer-reviewed nutrient absorption studies
95%
Standardized piperine content (vs ~6% in raw black pepper)
30%
Up to increased nutrient absorption in studies
Backed By Research
Shoba et al., 1998 (Planta Med)Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
BoronAM5mgBoron · Boron citrate+

A trace mineral that's been the subject of extensive research at the USDA's Grand Forks Human Nutrition Research Center. Studied for its role in bone health, cognitive performance, and hormonal balance in men.

  • Supports healthy hormonal balance in men
  • Helps maintain bone health and density
  • Supports cognitive function and short-term memory
  • Essential for proper calcium and magnesium metabolism
7 days
Time to observe hormonal effects in clinical studies
1981
Year boron's role in human metabolism was first established
Backed By Research
Pizzorno, 2015 (Integr Med)Nothing Boring About Boron — A comprehensive review of boron in human health.
Vitamin B12AM500mcgVitamin B12 · Methylcobalamin+

We use the active form, methylcobalamin — the form your body actually uses, not the cheaper synthetic cyanocobalamin. Up to 40% of adults over 45 have suboptimal B12 levels, and absorption naturally declines with age.

  • Essential for energy production from food
  • Supports nervous system and brain function
  • Required for red blood cell formation
  • Active methylcobalamin form (no conversion needed)
40%
Of adults 45+ have suboptimal B12 levels
20,833%
Of recommended daily value (high absorption form)
Backed By Research
NIH Office of Dietary SupplementsVitamin B12 Fact Sheet for Health Professionals.
MethylfolateAM400mcgMethylfolate · L-5-MTHF (active folate)+

The active, body-ready form of folate. Most supplements use folic acid — a synthetic form that requires conversion. Up to 60% of people carry an MTHFR gene variant that limits this conversion. Methylfolate skips that step entirely.

  • Active form — no MTHFR conversion needed
  • Supports cellular methylation processes
  • Essential for healthy mood regulation
  • Required for DNA synthesis and repair
60%
Of people carry an MTHFR variant affecting folic acid conversion
100%
Of recommended daily folate value
Backed By Research
Scaglione et al., 2014 (Xenobiotica)Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.
ChromiumAM200mcgChromium · Chromium picolinate+

An essential trace mineral that plays a critical role in glucose metabolism and insulin function. Found naturally in broccoli, whole grains, and lean meats — but typical Western diets often fall short of optimal intake.

  • Supports healthy glucose metabolism
  • Helps maintain insulin function
  • Essential for healthy macronutrient processing
  • Picolinate form — high bioavailability
571%
Of recommended daily value
1957
Year chromium was identified as essential to glucose metabolism
Backed By Research
NIH Office of Dietary SupplementsChromium Fact Sheet for Health Professionals.
KSM-66® AshwagandhaPM600mgKSM-66® Ashwagandha · Withania somnifera root+

The most clinically studied form of ashwagandha — a patented full-spectrum root extract with a 14-year development history. KSM-66 has appeared in 30+ peer-reviewed clinical trials and is the gold standard adaptogenic ingredient.

  • Supports the body's natural stress response
  • Helps maintain healthy cortisol levels
  • Promotes deeper, more restful sleep
  • Adaptogenic root used in Ayurveda for 3,000+ years
14 years
Of R&D went into developing the KSM-66 patent
30+
Peer-reviewed clinical trials on KSM-66 specifically
Backed By Research
Chandrasekhar et al., 2012 (Indian J Psychol Med)A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha in reducing stress and anxiety in adults.
Salve et al., 2019 (Cureus)Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study.
ShilajitPM200mgShilajit · Asphaltum / mineral pitch+

A blackish-brown resin that oozes from rocks in the Himalayan mountains during summer heat. Formed over millions of years from decomposed plant material — rich in fulvic acid and over 80 trace minerals.

  • Supports daily mineral and energy metabolism
  • Rich source of fulvic acid (a natural ionic carrier)
  • Contains 80+ trace minerals naturally
  • Used in Ayurvedic medicine for thousands of years
80+
Trace minerals naturally present in shilajit
Millions
Of years of natural formation in Himalayan rocks
Backed By Research
Pandit et al., 2016 (Andrologia)Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers.
TurmericPM200mgTurmeric · Curcuma longa (95% curcuminoids)+

One of the most-researched plants in modern medicine. Over 12,000 peer-reviewed papers have been published on curcumin — the active compound in turmeric. Used for thousands of years in Indian and Chinese medicine.

  • Supports the body's natural inflammatory response
  • Helps maintain joint comfort and mobility
  • Standardized to 95% curcuminoids (most potent form)
  • Combined with BioPerine for enhanced absorption
12,000+
Peer-reviewed studies on curcumin in PubMed
4,000+
Years of documented use in Ayurvedic medicine
Backed By Research
Hewlings & Kalman, 2017 (Foods)Curcumin: A Review of Its Effects on Human Health.
NAC (N-Acetyl Cysteine)PM200mgNAC (N-Acetyl Cysteine) · N-Acetyl-L-Cysteine+

The precursor to glutathione — the body's master antioxidant. NAC has been on the World Health Organization's List of Essential Medicines for liver protection since 1985, used in clinical settings for over 50 years.

  • Precursor to glutathione (master antioxidant)
  • Supports natural liver detoxification pathways
  • Helps maintain respiratory and immune health
  • Listed by WHO as an essential medicine since 1985
1985
Listed by WHO as an essential medicine
50+
Years of clinical use in hospital and research settings
Backed By Research
Mokhtari et al., 2017 (Cell J)A Review on Various Uses of N-Acetyl Cysteine.
L-TheaninePM200mgL-Theanine · From Camellia sinensis+

A unique amino acid found almost exclusively in green tea leaves. Promotes alpha brain wave activity — the relaxed-but-alert state monks achieve after years of meditation. Discovered in Japan in 1949.

  • Promotes a relaxed, focused mental state
  • Supports alpha brain wave activity
  • Helps the body wind down for sleep
  • Used in Japan since 1964 as a recognized food additive
1949
Year L-theanine was discovered in Japan
30-40 min
Time for alpha wave changes to show on EEG
Backed By Research
Nobre et al., 2008 (Asia Pac J Clin Nutr)L-theanine, a natural constituent in tea, and its effect on mental state.
Milk ThistlePM150mgMilk Thistle · Silybum marianum (silymarin)+

A spiny purple-flowered plant whose seeds contain silymarin — one of the most-studied natural liver support compounds in the world. Used since the time of Ancient Greek physicians, including Pliny the Elder and Dioscorides.

  • Supports natural liver detoxification
  • Helps maintain healthy liver function
  • Powerful antioxidant compound (silymarin)
  • Used medicinally for over 2,000 years
2,000+
Years of documented medicinal use
80%
Standardized silymarin content (most potent extract)
Backed By Research
Abenavoli et al., 2018 (Phytother Res)Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
GingerPM150mgGinger · Zingiber officinale root+

One of the oldest medicinal foods on earth. Active gingerols and shogaols have been the subject of over 5,000 PubMed studies. Native to Southeast Asia, ginger has been part of Ayurvedic and Chinese traditional medicine for over 5,000 years.

  • Supports the body's natural inflammatory response
  • Helps maintain healthy digestion
  • Promotes circulation and warmth
  • Active compounds: gingerols and shogaols
5,000+
Years of medicinal use across cultures
5,000+
Peer-reviewed PubMed studies on ginger compounds
Backed By Research
Mashhadi et al., 2013 (Int J Prev Med)Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity.
Magnesium GlycinatePM100mgMagnesium Glycinate · Magnesium bisglycinate chelate+

The most bioavailable, gentlest form of magnesium. Required for over 600 enzymatic reactions in the human body. Up to 50% of Americans don't get enough magnesium — and the glycinate form is best for sleep and relaxation.

  • Promotes deep sleep and relaxation
  • Supports muscle recovery and nervous system
  • Bisglycinate chelate — gentle on the stomach
  • Required for 600+ enzymatic reactions
600+
Enzymatic reactions require magnesium
50%
Of Americans don't meet the daily magnesium intake
Backed By Research
NIH Office of Dietary SupplementsMagnesium Fact Sheet for Health Professionals.
DIMPM50mgDIM · Diindolylmethane (from cruciferous vegetables)+

A natural compound formed when you eat cruciferous vegetables — broccoli, kale, cabbage, Brussels sprouts. Studied for its role in healthy hormone metabolism in both men and women.

  • Supports healthy estrogen metabolism in men
  • Helps maintain hormonal balance with age
  • Derived from cruciferous vegetable compounds
  • Used in research at major US universities
2 lbs
Of broccoli daily would equal this DIM dose
1990s
Decade DIM research began at major universities
Backed By Research
Thomson et al., 2016 (Mol Nutr Food Res)Diindolylmethane (DIM): Bioactive compound from cruciferous vegetables — a review.
ZincPM14mgZinc · Zinc bisglycinate chelate+

Essential for over 300 enzymes in the human body — including those involved in immune function, hormonal balance, and DNA synthesis. The bisglycinate chelate form is among the most absorbable.

  • Essential for healthy immune function
  • Supports natural hormonal balance in men
  • Required for taste, smell, and wound healing
  • Bisglycinate chelate — superior absorption
300+
Enzymes require zinc to function properly
127%
Of recommended daily value
Backed By Research
NIH Office of Dietary SupplementsZinc Fact Sheet for Health Professionals.
BioPerine®PM10mgBioPerine® · Piper nigrum (95% piperine)+

The patented standardized extract of black pepper. Critical for absorption of curcumin in the PM formula — without piperine, less than 5% of curcumin reaches the bloodstream. With it, absorption increases significantly.

  • Increases bioavailability of co-administered nutrients
  • Critical for turmeric/curcumin absorption
  • Patented extract from Sabinsa Corporation
  • Used in 100+ peer-reviewed nutrient absorption studies
2000%
Increase in curcumin absorption when paired with piperine
95%
Standardized piperine content (vs ~6% in raw black pepper)
Backed By Research
Shoba et al., 1998 (Planta Med)Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
Vitamin B6 (P5P)PM5mgVitamin B6 (P5P) · Pyridoxal-5-Phosphate+

We use the active P5P form — the form your liver normally has to create from regular B6. Essential for over 100 enzymatic reactions, especially those involved in mood, sleep, and protein metabolism.

  • Active P5P form — no liver conversion needed
  • Supports neurotransmitter synthesis (serotonin, melatonin)
  • Helps maintain healthy mood and sleep
  • Required for over 100 enzymatic reactions
100+
Enzymes require active P5P to function
294%
Of recommended daily value
Backed By Research
NIH Office of Dietary SupplementsVitamin B6 Fact Sheet for Health Professionals.
SeleniumPM30mcgSelenium · L-Selenomethionine+

A trace mineral that's essential for thyroid function and antioxidant defense. Forms the active center of glutathione peroxidase — one of your body's most important antioxidant enzymes. Naturally found in Brazil nuts.

  • Essential for healthy thyroid function
  • Component of glutathione peroxidase (key antioxidant enzyme)
  • Supports immune system function
  • L-Selenomethionine — most bioavailable form
25+
Selenoproteins identified in the human body
55%
Of recommended daily value
Backed By Research
NIH Office of Dietary SupplementsSelenium Fact Sheet for Health Professionals.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any new supplement.

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